Mucuna pruriens and L-dopa

Your Natural Source of L-DOPA.

Unlock the power of nature with Mucuna pruriens (L.) DC var. pruriens, the ultimate solution for enhancing dopamine levels in your body. As you may know, dopamine is a vital neurotransmitter used in the treatment of Parkinson’s disease, and Mucuna pruriens is here to offer you a natural source of its precursor, L-DOPA.

Study

This groundbreaking study reveals the fascinating synthesis pathways within this remarkable plant. Through the catecholamine (CA) pathway, Mucuna pruriens produces L-DOPA with the help of two incredible enzymes: tyrosine hydroxylase (TH) and polyphenol oxidase (PPO). This unique process sets Mucuna pruriens apart as an exceptional natural resource for L-DOPA production.

In the rigorous analysis, we explored different tissues and callus cultures, meticulously examining the metabolite profiles and gene expressions involved in dopamine formation. By employing advanced techniques such as NMR spectroscopy and HPLC, we accurately detected and quantified the four major intermediates: L-tyrosine, tyramine, L-DOPA, and dopamine.

Results

The results were astounding! Our findings showcase the prominent role of PPO in converting L-tyrosine into dopamine through L-DOPA, surpassing dopamine production from tyramine. With a staggering 6.5 times higher activity than TH in metabolically active young leaves, PPO demonstrates its dominance in driving L-DOPA synthesis.

By validating the CA pathway-mediated synthesis of L-DOPA with PPO as the leading enzyme, this study solidifies the extraordinary potential of Mucuna pruriens as your go-to natural solution. Embrace the power of this remarkable plant and experience the benefits it offers for boosting dopamine levels and supporting your well-being.

Don’t miss out on the wonders of Mucuna pruriens. Discover the natural path to increased dopamine with our groundbreaking solution. Try Mucuna pruriens today and unlock a brighter, healthier future!

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Article

Plant Physiology and Biochemistry

September 2021;166:1032-1043. doi: 10.1016/j.plaphy.2021.06.053. Epub 2021 July 8.

Polyphenol oxidase (PPO) arm of the catecholamine pathway catalyzes the conversion of L-tyrosine to L-DOPA in Mucuna pruriens (L.) DC var. pruriens: an integrated pathway analysis using field-grown and in vitro callus cultures

G Saranya 1, D Sruthi 2, KS Jayakuma 3, MV Jiby 2, R Aswati Nair 4, Padmesh P Pillai 5, C Jayabaskaran 2

PMID: 34274890 DOI: 10.1016/j.plaphy.2021.06.053